And all the true fans know that this wasn’t Zac and Nicole’s first movie together…or even their first time playing love interests. The duo first starred opposite each other in the 2012 thriller The Paperboy.
So, here are 15 more celebrity duos that have such great chemistry they’ve played love interests more than once:
1.
Timothée Chalamet and Saoirse Ronan have been in three movies together and played love interests in two: Lady Bird (2017) and Little Women (2019), both directed by Greta Gerwig.
2.
Emma Stone and Ryan Gosling have played love interests in all three movies they starred in together: Crazy, Stupid, Love (2011), Gangster Squad (2013), and La La Land (2016).
3.
Amy Adams and Christian Bale played opposite each other as love interests in American Hustle (2013) and Vice (2018).
4.
Javier Bardem and Penélope Cruz played opposite each other in four movies: Jamón, Jamón (1992), Vicky Cristina Barcelona (2008), Loving Pablo (2017), and Everybody Knows (2018).
5.
Adam Sandler and Drew Barrymore have played love interests in three movies: The Wedding Singer (1998), 50 First Dates (2004), and Blended (2014).
6.
Jennifer Aniston has also starred alongside Adam Sandler in several movies, and they’ve played love interests three times in the movies Just Go With It (2011), Murder Mystery (2019), and Murder Mystery 2 (2023).
7.
Sanaa Lathan and Omar Epps played love interests in both movies they starred in together: The Wood (1999) and Love & Basketball (2000).
8.
Kristen Stewart and Jesse Eisenberg have starred opposite each other as love interests in three movies: Adventureland (2009), American Ultra (2015), and Café Society (2016).
9.
Tom Hanks and Meg Ryan have played love interests in all four movies they’ve starred in together: Joe Versus the Volcano (1990), Sleepless in Seattle (1993), You’ve Got Mail (1998), and Ithaca (2015).
10.
Jennifer Lawrence and Bradley Cooper have been in four movies together, but only played love interests in two: Silver Linings Playbook (2013) and Serena (2014).
11.
Matthew McConaughey and Kate Hudson played opposite each other as love interests in How to Lose a Guy in 10 Days (2003) and Fool’s Gold (2008).
12.
Kate Winslet and Leonardo DiCaprio have played opposite each other as love interests in Titanic (1997) and Revolutionary Road (2008).
13.
Winona Ryder and Keanu Reeves starred as love interests in three of the four movies they’ve done together: Bram Stoker’s Dracula (1992), A Scanner Darkly (2006), and Destination Wedding (2018).
14.
Eugene Levy and Catherine O’Hara have played a couple in Best in Show (2000), A Mighty Wind (2003), and Schitt’s Creek (2015–2020).
15.
Finally, Jennifer Garner and Mark Ruffalo play opposite each other as love interests in 13 Going on 30 (2004) and The Adam Project (2022).
![‘Our Hero, Balthazar’ Thwarts a Would-Be School Shooter in First Images For Wild Satire Starring Noah Centineo and Asa Butterfield [Exclusive]](https://static1.colliderimages.com/wordpress/wp-content/uploads/2025/06/untitled-design-70.jpg "‘Our Hero, Balthazar’ Thwarts a Would-Be School Shooter in First Images For Wild Satire Starring Noah Centineo and Asa Butterfield [Exclusive]")
